484 research outputs found
Improvement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment
Purpose: The goal of this study was to determine if continuous application of insulin-like growth factor-1 (IGF-1) could improve eye alignment of adult strabismic nonhuman primates and to assess possible mechanisms of effect. Methods: A continuous release pellet of IGF-1 was placed on one medial rectus muscle in two adult nonhuman primates (M1, M2) rendered exotropic by the alternating monocular occlusion method during the first months of life. Eye alignment and eye movements were recorded for 3 months, after which M1 was euthanized, and the lateral and medial rectus muscles were removed for morphometric analysis of fiber size, nerve, and neuromuscular density. Results: Monkey 1 showed a 40% reduction in strabismus angle, a reduction of exotropia of approximately 11° to 14° after 3 months. Monkey 2 showed a 15% improvement, with a reduction of its exotropia by approximately 3°. The treated medial rectus muscle of M1 showed increased mean myofiber cross-sectional areas. Increases in myofiber size also were seen in the contralateral medial rectus and lateral rectus muscles. Similarly, nerve density increased in the contralateral medial rectus and yoked lateral rectus. Conclusions: This study demonstrates that in adult nonhuman primates with a sensory-induced exotropia in infancy, continuous IGF-1 treatment improves eye alignment, resulting in muscle fiber enlargement and altered innervational density that includes the untreated muscles. This supports the view that there is sufficient plasticity in the adult ocular motor system to allow continuous IGF-1 treatment over months to produce improvement in eye alignment in early-onset strabismus
Unilateral Familial Exudative Vitreoretinopathy: Clinical Profile and Pathology
We report a case of a newborn with unilateral retinal detachment that could not be repaired. At examination under anesthesia, the retina was markedly abnormal and a presumptive diagnosis of retinal dysplasia was made. Several years later, the eye was enucleated because it was blind and painful. Final pathology was consistent with familial exudative vitreoretinopathy (FEVR). The literature describing unilateral retinal dysplasia is sparse. This case adds to the clinical spectrum of pathologic findings in FEVR
Acute leukaemoid reaction following cardiac surgery
Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress. Cardiac surgery activates many inflammatory cascades and may precipitate a systemic inflammatory response syndrome. We present a case of undiagnosed chronic myelomonocytic leukaemia who developed rapidly fatal multi-organ dysfunction following cardiac surgery due to an acute leukaemoid reaction
Revisiting the HIP 41378 System with K2 and Spitzer
We present new observations of the multiplanet system HIP 41378, a bright star (V = 8.9, K s = 7.7) with five known transiting planets. Previous K2 observations showed multiple transits of two Neptune-sized bodies and single transits of three larger planets (R P = 0.33R J , 0.47R J , 0.88R J ). K2 recently observed the system again in Campaign 18 (C18). We observe one new transit each of two of the larger planets d/f, giving maximal orbital periods of 1114/1084 days, as well as integer divisions of these values down to a lower limit of about 50 days. We use all available photometry to determine the eccentricity distributions of HIP 41378 d & f, finding that periods lesssim300 days require non-zero eccentricity. We check for overlapping orbits of planets d and f to constrain their mutual periods, finding that short periods (P < 300 days) for planet f are disfavored. We also observe transits of planets b and c with Spitzer/Infrared Array Camera (IRAC), which we combine with the K2 observations to search for transit timing variations (TTVs). We find a linear ephemeris for planet b, but see a significant TTV signal for planet c. The ability to recover the two smaller planets with Spitzer shows that this fascinating system will continue to be detectable with Spitzer, CHEOPS, TESS, and other observatories, allowing us to precisely determine the periods of d and f, characterize the TTVs of planet c, recover the transits of planet e, and further enhance our view of this remarkable dynamical laboratory
Kepler Mission Stellar and Instrument Noise Properties
Kepler Mission results are rapidly contributing to fundamentally new
discoveries in both the exoplanet and asteroseismology fields. The data
returned from Kepler are unique in terms of the number of stars observed,
precision of photometry for time series observations, and the temporal extent
of high duty cycle observations. As the first mission to provide extensive time
series measurements on thousands of stars over months to years at a level
hitherto possible only for the Sun, the results from Kepler will vastly
increase our knowledge of stellar variability for quiet solar-type stars. Here
we report on the stellar noise inferred on the timescale of a few hours of most
interest for detection of exoplanets via transits. By design the data from
moderately bright Kepler stars are expected to have roughly comparable levels
of noise intrinsic to the stars and arising from a combination of fundamental
limitations such as Poisson statistics and any instrument noise. The noise
levels attained by Kepler on-orbit exceed by some 50% the target levels for
solar-type, quiet stars. We provide a decomposition of observed noise for an
ensemble of 12th magnitude stars arising from fundamental terms (Poisson and
readout noise), added noise due to the instrument and that intrinsic to the
stars. The largest factor in the modestly higher than anticipated noise follows
from intrinsic stellar noise. We show that using stellar parameters from
galactic stellar synthesis models, and projections to stellar rotation,
activity and hence noise levels reproduces the primary intrinsic stellar noise
features.Comment: Accepted by ApJ; 26 pages, 20 figure
Kepler-20: A Sun-like Star with Three Sub-Neptune Exoplanets and Two Earth-size Candidates
We present the discovery of the Kepler-20 planetary system, which we
initially identified through the detection of five distinct periodic transit
signals in the Kepler light curve of the host star 2MASSJ19104752+4220194. We
find a stellar effective temperature Teff=5455+-100K, a metallicity of
[Fe/H]=0.01+-0.04, and a surface gravity of log(g)=4.4+-0.1. Combined with an
estimate of the stellar density from the transit light curves we deduce a
stellar mass of Mstar=0.912+-0.034 Msun and a stellar radius of
Rstar=0.944^{+0.060}_{-0.095} Rsun. For three of the transit signals, our
results strongly disfavor the possibility that these result from astrophysical
false positives. We conclude that the planetary scenario is more likely than
that of an astrophysical false positive by a factor of 2e5 (Kepler-20b), 1e5
(Kepler-20c), and 1.1e3 (Kepler-20d), sufficient to validate these objects as
planetary companions. For Kepler-20c and Kepler-20d, the blend scenario is
independently disfavored by the achromaticity of the transit: From Spitzer data
gathered at 4.5um, we infer a ratio of the planetary to stellar radii of
0.075+-0.015 (Kepler-20c) and 0.065+-0.011 (Kepler-20d), consistent with each
of the depths measured in the Kepler optical bandpass. We determine the orbital
periods and physical radii of the three confirmed planets to be 3.70d and
1.91^{+0.12}_{-0.21} Rearth for Kepler-20b, 10.85 d and 3.07^{+0.20}_{-0.31}
Rearth for Kepelr-20c, and 77.61 d and 2.75^{+0.17}_{-0.30} Rearth for
Kepler-20d. From multi-epoch radial velocities, we determine the masses of
Kepler-20b and Kepler-20c to be 8.7\+-2.2 Mearth and 16.1+-3.5 Mearth,
respectively, and we place an upper limit on the mass of Kepler-20d of 20.1
Mearth (2 sigma).Comment: accepted by ApJ, 58 pages, 12 figures revised Jan 2012 to correct
table 2 and clarify planet parameter extractio
TESS Discovery of a Transiting Super-Earth in the Mensae System
We report the detection of a transiting planet around Mensae (HD
39091), using data from the Transiting Exoplanet Survey Satellite (TESS). The
solar-type host star is unusually bright (V=5.7) and was already known to host
a Jovian planet on a highly eccentric, 5.7-year orbit. The newly discovered
planet has a size of and an orbital period of 6.27
days. Radial-velocity data from the HARPS and AAT/UCLES archives also displays
a 6.27-day periodicity, confirming the existence of the planet and leading to a
mass determination of . The star's proximity and
brightness will facilitate further investigations, such as atmospheric
spectroscopy, asteroseismology, the Rossiter--McLaughlin effect, astrometry,
and direct imaging.Comment: Accepted for publication ApJ Letters. This letter makes use of the
TESS Alert data, which is currently in a beta test phase. The discovery light
curve is included in a table inside the arxiv submissio
Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data
New transiting planet candidates are identified in sixteen months (May 2009 -
September 2010) of data from the Kepler spacecraft. Nearly five thousand
periodic transit-like signals are vetted against astrophysical and instrumental
false positives yielding 1,091 viable new planet candidates, bringing the total
count up to over 2,300. Improved vetting metrics are employed, contributing to
higher catalog reliability. Most notable is the noise-weighted robust averaging
of multi-quarter photo-center offsets derived from difference image analysis
which identifies likely background eclipsing binaries. Twenty-two months of
photometry are used for the purpose of characterizing each of the new
candidates. Ephemerides (transit epoch, T_0, and orbital period, P) are
tabulated as well as the products of light curve modeling: reduced radius
(Rp/R*), reduced semi-major axis (d/R*), and impact parameter (b). The largest
fractional increases are seen for the smallest planet candidates (197% for
candidates smaller than 2Re compared to 52% for candidates larger than 2Re) and
those at longer orbital periods (123% for candidates outside of 50-day orbits
versus 85% for candidates inside of 50-day orbits). The gains are larger than
expected from increasing the observing window from thirteen months (Quarter 1--
Quarter 5) to sixteen months (Quarter 1 -- Quarter 6). This demonstrates the
benefit of continued development of pipeline analysis software. The fraction of
all host stars with multiple candidates has grown from 17% to 20%, and the
paucity of short-period giant planets in multiple systems is still evident. The
progression toward smaller planets at longer orbital periods with each new
catalog release suggests that Earth-size planets in the Habitable Zone are
forthcoming if, indeed, such planets are abundant.Comment: Submitted to ApJS. Machine-readable tables are available at
http://kepler.nasa.gov, http://archive.stsci.edu/kepler/results.html, and the
NASA Exoplanet Archiv
Kepler-21b: A 1.6REarth Planet Transiting the Bright Oscillating F Subgiant Star HD 179070
We present Kepler observations of the bright (V=8.3), oscillating star HD
179070. The observations show transit-like events which reveal that the star is
orbited every 2.8 days by a small, 1.6 R_Earth object. Seismic studies of HD
179070 using short cadence Kepler observations show that HD 179070 has a
frequencypower spectrum consistent with solar-like oscillations that are
acoustic p-modes. Asteroseismic analysis provides robust values for the mass
and radius of HD 179070, 1.34{\pm}0.06 M{\circ} and 1.86{\pm}0.04 R{\circ}
respectively, as well as yielding an age of 2.84{\pm}0.34 Gyr for this F5
subgiant. Together with ground-based follow-up observations, analysis of the
Kepler light curves and image data, and blend scenario models, we
conservatively show at the >99.7% confidence level (3{\sigma}) that the transit
event is caused by a 1.64{\pm}0.04 R_Earth exoplanet in a 2.785755{\pm}0.000032
day orbit. The exoplanet is only 0.04 AU away from the star and our
spectroscopic observations provide an upper limit to its mass of ~10 M_Earth
(2-{\sigma}). HD 179070 is the brightest exoplanet host star yet discovered by
Kepler.Comment: Accepted to Ap
Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis
Osteoarthritis (OA) is the most common joint disease, affecting over 300 million people world-wide. Accumulating evidence attests to the important roles of the immune system in OA pathogenesis. Understanding the role of various immune cells in joint degeneration or joint repair after injury is vital for improving therapeutic strategies for treating OA. Post-traumatic osteoarthritis (PTOA) develops in ~50% of individuals who have experienced an articular trauma like an anterior cruciate ligament (ACL) rupture. Here, using the high resolution of single-cell RNA sequencing, we delineated the temporal dynamics of immune cell accumulation in the mouse knee joint after ACL rupture. Our study identified multiple immune cell types in the joint including neutrophils, monocytes, macrophages, B cells, T cells, NK cells and dendritic cells. Monocytes and macrophage populations showed the most dramatic changes after injury. Further characterization of monocytes and macrophages reveled 9 major subtypes with unique transcriptomics signatures, including a tissue resident Lyve1hiFolr2hi macrophage population and Trem2hiFcrls+ recruited macrophages, both showing enrichment for phagocytic genes and growth factors such as Igf1, Pdgfa and Pdgfc. We also identified several genes induced or repressed after ACL injury in a cell type-specific manner. This study provides new insight into PTOA-associated changes in the immune microenvironment and highlights macrophage subtypes that may play a role in joint repair after injury
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